Anisomycin and the reconsolidation hypothesis
نویسندگان
چکیده
منابع مشابه
Anisomycin and the reconsolidation hypothesis.
For over 30 years researchers have suspected that the very act of retrieving a memory places it in a labile state and leaves it vulnerable to subsequent challenges that affect the brain. Misanin et al. (1968) provided the initial empirical basis for this claim when they reported that electroconvulsive shock (ECS) presented immediately following a brief presentation of a fear-conditioned CS prod...
متن کاملExtinction learning, reconsolidation and the internal reinforcement hypothesis.
Retrieving a consolidated memory--by exposing an animal to the learned stimulus but not to the associated reinforcement--leads to two opposing processes: one that weakens the old memory as a result of extinction learning, and another that strengthens the old, already-consolidated memory as a result of some less well-understood form of learning. This latter process of memory strengthening is oft...
متن کاملEffects of anisomycin on consolidation and reconsolidation of a morphine-conditioned place preference.
Protein synthesis inhibitors block consolidation of memory and may also block the reconsolidation of a reactivated memory in paradigms of aversive learning, but the evidence for reconsolidation effects is conflicting in appetitive paradigms. We now report that intra-cerebroventricular (ICV) anisomycin (400microg) prevents consolidation of morphine-induced place preference (CPP), but does not im...
متن کاملRites of Passage of the Engram Reconsolidation and the Lingering Consolidation Hypothesis
Memory consolidation refers to the progressive stabilization of items in long-term memory as well as to the memory phase(s) during which this stabilization takes place. The textbook account is that, for each item in memory, consolidation starts and ends just once. In recent years, however, the notion that memories reconsolidate upon their reactivation and hence regain sensitivity to amnestic ag...
متن کاملConsolidation and reconsolidation of memory in black-capped chickadees (Poecile atricapillus).
Multiple phases of protein synthesis are necessary for the synaptic modifications that consolidate long-term memory. The reconsolidation hypothesis supposes that information in long-term memory becomes labile and subject to change when retrieved and must be reconsolidated into long-term memory. The current study used the protein synthesis inhibitor anisomycin to examine memory consolidation in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Learning & Memory
سال: 2006
ISSN: 1072-0502
DOI: 10.1101/lm.157806